Senior/Principal Scientist, Translational Medicine Mass Spectrometry

12 Month Contract (May extend or convert to perm) $83.45/hour - $103.45/hour W2 (Depending on previous

experience)

Position Details: The Translational Medicine department informs clinical development of novel personalized therapeutics through establishment of biomarker strategies aimed to study biological pathways driving disease and by characterizing the mechanism of action of novel therapeutics.As a key member of the biomarker mass spectrometry laboratory, the ideal candidate will utilize mass spectrometry to explore novel biomarker hypotheses, assist in streamlining existing workflows, and help to drive innovation within the group through improved LC-MS/MS method development.

Experience/

Skills

Experience in clinical proteomics and clinical sample processing is required. Hands-on

experience with maintaining LC and MS instrumentation is also required.PhD in Analytical Chemistry, Biochemistry, or Biotechnology and successful postdoctoral research training in a related fieldMinimum of 6 years of hands-on

experience with liquid chromatography and tandem mass spectrometry (LC-MS/MS) approaches, and have excellent troubleshooting capabilitiesStrong analytical background with fundamentals in assay development, system suitability, and method evaluation

Experience with discovery proteomics approaches (TMT, DIA-MS, SWATH, etc.) and corresponding data analysis toolsKnowledge of sample preparation techniques for analysis of biomarkers and other mediators from biological fluids (e.g. plasma, CSF, urine, stool, etc.)A proven ability to analyze and visualize complex datasets using tools like MSstats, Spotfire, R, or Skyline and

experience with standard instrument software such as Analyst or Xcalibur